Full publication list PubMed
Selected publications:
Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature.
Madden K, El Hamra R, Berton S, Felker J, Alvarez GG, Alexandre Blais, Jim Sun.
Microlife. 2023 Feb 6;4:uqad006 Abstract
Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter.
Girgis J, Yang D, Chakroun I, Liu Y, Alexandre Blais.
Skelet Muscle. 2021 Nov 19;11(1):26 Abstract
Gene expression profiling of skeletal myogenesis in human
embryonic stem cells reveals a potential cascade of transcription
factors regulating stages of myogenesis, including quiescent/activated
satellite cell-like gene expression.
Shelton M, Ritso M, Liu J, O'Neil D, Kocharyan A, Rudnicki MA, Stanford WL, Skerjanc IS, Alexandre Blais.
PLoS One. 2019 Sep 27;14(9):e0222946 Abstract
BRG1 interacts with GLI2 and binds Mef2c gene in a hedgehog signalling dependent manner during in vitro cardiomyogenesis.
Fair JV, Voronova A, Bosiljcic N, Rajgara R, Alexandre Blais, Ilona S. Skerjanc.
BMC Dev Biol. 2016 Aug 2;16(1):27 Abstract
Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis.
Chakroun I, Yang D, Girgis J, Gunasekharan A, Phenix H, Kærn M, Alexandre Blais.
FASEB J. 2015 Nov;29(11):4738-55. Abstract
Julian LM, Alexandre Blais.
Front Genet. 2015 Apr 28;6:161. Abstract
Myogenesis in the genomics era
Alexandre Blais.
J Mol Biol. 2015 Jun 5;427(11):2023-38. Abstract
Six1 regulates MyoD expression in adult muscle progenitor cells.
Yubing Liu, Iman Chakroun, Dabo Yang, Ellias Horner, Jieyi Liang, Arif Aziz, Alphonse Chu, Yves De Repentigny, F. Jeffrey Dilworth, Rashmi Kothary and Alexandre Blais.
PLoS One. 2013 Jun 28;8(6):e67762 Abstract
Rb and chromatin remodeling in the maintenance of the post-mitotic state of neurons.
Alexandre Blais (2013).
Cell Cycle. 2013 Jun 1;12(11):1661-2. Abstract
Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor.
Yubing Liu, Soumyadeep Nandi, André Martel, Alen Antoun, Ilya Ioshikhes and Alexandre Blais (2012).
Nucleic Acids Research, 40(17):8227-39 Abstract
A new mode of cell cycle stimulation: Cyclin E and CDK2-mediated cytoplasmic retention of repressive E2F complexes.
Alexandre Blais (2012).
Cell Cycle, Aug 15;11(16). Abstract
Epigenetic regulation of satellite cells in muscle regeneration.
F. Jeffrey Dilworth and Alexandre Blais (2011).
Stem Cell Research and Therapy, 2(2):18. Abstract
Cooperation Between Myogenic Regulatory Factors and SIX Family Transcription Factors is Important for Myoblast Differentiation.
Yubing Liu, Alphonse Chu, Imane Chakroun, Uzma Islam, Alexandre Blais. (2010).
Nucleic Acids Research, 38(20):6857-71. Abstract
Other work
Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.
Ghorbani
P, Kim SY, Smith TKT, Minarrieta L, Robert-Gostlin V, Kilgour MK,
Ilijevska M, Alecu I, Snider SA, Margison KD, Nunes JRC, Woo D, Pember
C, O'Dwyer C, Ouellette J, Kotchetkov P, St-Pierre J, Bennett SAL,
Lacoste B, Alexandre Blais, Nair MG, Morgan D. Fullerton.
PLoS Pathog. 2023 Sep 25;19(9):e1011658 Abstract
ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses.
Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, Geoffrion M, Yang D, Harper ME, Rayner K, Alexandre Blais, Jim Sun.
J Leukoc Biol. 2023 Sep 1;114(3):280-298 Abstract
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.
Hajjar S, Nathan N, Joseph J, Mottawea W, Ariana A, Pyatibrat S, Harper ME, Alain T, Alexandre Blais, Russell RC, Subash Sad.
Cell Death Differ. 2022 Mar;29(3):585-599 Abstract
Chromatin and transcription factor profiling in rare stem cell populations using CUT&Tag.
Li Y, Nakka K, Olender T, Gingras-Gelinas P, Wong MM, Robinson DCL, Bandukwala H, Palii CG, Neyret O, Brand M, Alexandre Blais, F. Jeffrey Dilworth.
STAR Protoc. 2021 Aug 19;2(3):100751 Abstract
Muscle Enriched Lamin Interacting Protein (Mlip) Binds Chromatin and Is Required for Myoblast Differentiation.
Ahmady E, Alexandre Blais, Patrick G. Burgon.
Cells. 2021 Mar 10;10(3):615 Abstract
Combinatorial Utilization of Murine Embryonic Stem Cells and In Vivo Models to Study Human Congenital Heart Disease.
Zakariyah A, Rajgara R, Shelton M, Alexandre Blais, Skerjanc IS, Patrick G. Burgon.
Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e75 Abstract
In Vitro Modeling of Congenital Heart Defects Associated with an NKX2-5 Mutation Revealed a Dysregulation in BMP/Notch-Mediated Signaling.
Zakariyah AF, Rajgara RF, Horner E, Cattin ME, Alexandre Blais, Skerjanc IS, Patrick G. Burgon.
Stem Cells. 2018 Apr;36(4):514-526 Abstract
Hamed M, Khilji S, Dixon K, Alexandre Blais, Ioshikhes I, Chen J, Qiao Li.
Nucleic Acids Res. 2017 Nov 2;45(19):11236-11248. Abstract
SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
Rajgara RF, Lala-Tabbert N, Marchildon F, Lamarche É, MacDonald JK, Scott DA, Alexandre Blais, Skerjanc IS, Nadine Wiper-Bergeron.
Stem Cell Reports. 2017 Oct 10;9(4):1139-1151. Abstract
A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs.
Moreira S, Polena E, Gordon V, Abdulla S, Mahendram S, Cao J, Alexandre Blais, Wood GA, Dvorkin-Gheva A, Bradley W. Doble.
Cell Rep. 2017 Sep 5;20(10):2424-2438. Abstract
Molecular basis for the methylation specificity of ATXR5 for histone H3.
Bergamin E, Sarvan S, Malette J, Eram MS, Yeung S, Mongeon V, Joshi M, Brunzelle JS, Michaels SD, Alexandre Blais, Vedadi M, Jean-François Couture.
Nucleic Acids Res. 2017 Jun 20;45(11):6375-6387. Abstract
Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.
Tobin SW, Yang D, Girgis J, Farahzad A, Alexandre Blais, John C. McDermott.
J Cell Sci.2016 Nov 1;129(21):4076-4090. Abstract
Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium.
Joseph J, Ametepe ES, Haribabu N, Agbayani G, Krishnan L, Alexandre Blais, Subash Sad.
Nat Commun. 2016 Sep 7;7:12748. Abstract
Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling.
Wales S, Hashemi S, Alexandre Blais, John C. McDermott.
Nucleic Acids Res. 2014 Oct;42(18):11349-62. Abstract
Keeping them all together: β-propeller domains in histone methyltransferase complexes.
Bergamin E, Alexandre Blais, Jean-François Couture.
J Mol Biol. 2014 Oct 9;426(20):3363-75. Abstract
Identification of cis-regulatory modules in promoters of human genes exploiting mutual positioning of transcription factors.
Soumyadeep Nandi, Alexandre Blais and Ilya Ioshikhes(2013).
Nucleic Acids Research, 40(17):8227-39 Abstract
Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells.
Lisa M. Julian, Catherine A. Pakenham, Renaud Vandenbosch, Devon Svoboda, Kelly A. McClellan, David S. Park, Gustavo Leone, Alexandre Blais* and Ruth Slack*(2012).
Cell Stem Cell, 2013 Mar 13 Abstract
The Rb/E2F Pathway Modulates Neurogenesis through Direct Regulation of the Dlx1/Dlx2 Bigene Cluster.
Noël
Ghanem, Matthew G Andrusiak, Devon Svoboda, Sawsan M Al Lafi, Lisa M
Julian, Kelly A McClellan, Yves De Repentigny, Rashmi Kothary, Marc
Ekker, Alexandre Blais, David S Park, Ruth S Slack (2012).
The Journal of Neuroscience 32 (24), 8219-8230. Abstract
Microtubule stability, Golgi organization, and transport flux require dystonin-a2/MAP1B interaction.
Scott D. Ryan, Kunal Bhanot, Yves De Repentigny, Alphonse Chu, Alexandre Blais, and Rashmi Kothary (2012).
Journal of Cell Biology,196(6):727-42. Abstract
Retinoic Acid Enhances Skeletal Myogenesis in Human Embryonic Stem Cells by Expanding the Premyogenic Progenitor Population.
T. Ryan, J. Liu, Alphonse Chu, L. Wang, Alexandre Blais, and I.S. Skerjanc (2011).
Stem Cell Reviews, Epub ahead of print. Abstract
Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.
S. Sarvan, V. Avdic, V. Tremblay, C.P. Chaturvedi, P. Zhang, S. Lanouette, Alexandre Blais, J.S. Brunzelle, M. Brand, and J.F. Couture.
Nature Structural and Molecular Biology. 2011 Jun 5;18(7):857-9. Abstract
Lipin - The Bridge between Hepatic Glycerolipid Biosynthesis and Lipoprotein Metabolism.
Maroun Bou Khalil, Alexandre Blais, Daniel Figeys and Zemin Yao (2010).
BBA - Molecular and Cell Biology of Lipids, 1801(12):1249-59. Abstract
The mammalian Sin3 complex is required for muscle development and sarcomere specification.
Chris van Oevelen, Christopher Bowman, Jessica Pellegrino, Patrik Asp,
Jemmie Cheng, Fabio Parisi, Mariann Micsinai, Yuval Kluger, Alphonse
Chu, Alexandre Blais, Gregory David, and Brian D. Dynlacht. (2010).
Molecular and Cellular Biology, 30(24):5686-97. Abstract
UTX-mediated
demethylation of nucleosomes occurs through a two-step mechanism to
activate developmentally-regulated gene expression.
Shayesta Seenundun, Shravanti Rampalli, Qi-Cai Liu, SunHwa Hong, Carmen Palii, Alexandre Blais, Marjorie Brand, Kai Ge, F. Jeffrey Dilworth (2009).
EMBO Journal, 29(8): 1401-11. Abstract
Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome.
Claire Niro, Josiane Demignon, Stéphane Vincent, Yubing Liu, Julien Giordani, Maryline Favier, Isabelle Guillet-Deniau, Alexandre Blais, Pascal Maire (2009).
Developmental Biology, 15;338(2):168-82. Abstract
SOX15 and SOX7 Differentially Regulate the Myogenic Program in P19 Cells.
Josée Savage, Andrew Conley, Alexandre Blais, Ilona Skerjanc (2009).
Stem Cells, 27(6):1231-43. Abstract
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Traf7, a MyoD1 transcriptional target, regulates NFKB activity during myogenesis.
Mary Tsikitis, Diego Acosta-Alvear, Alexandre Blais, Eric I. Campos, William Lane, Irma Sánchez, and Brian David Dynlacht (2010).
EMBO Reports, 11(12):969-76. Abstract
pRb-specific methylation of histone H3 lysine 27 is associated to irreversible cell cycle exit.
Alexandre Blais, Chris J.C. van Oevelen, Diego Acosta-Alvear, and Brian David Dynlacht (2007).
Journal of Cell Biology, 179(7): 1399-1412. Abstract
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Raphael Margueron, Guohong Li, Kavitha Sarma, Alexandre Blais, Jiri Zivadil, Brian Dynlacht, and Danny Reinberg (2008).
Mol Cell. 32(4):503-18. Abstract
E2F-associated chromatin modifiers and cell cycle control.
Alexandre Blais and Brian D. Dynlacht (2007).
Current Opinions in Cell Biology. 19(6):658-62. Abstract
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
Diego Acosta-Alvear, Yiming Zhou, Alexandre Blais, Mary Tsikitis, Nathan H. Lents, Carolina Arias, Christen J. Lennon, Yuval Kluger, and Brian David Dynlacht (2007).
Mol. Cell, 27:53-66. Abstract
Functional genomics via multiscale analysis: application to gene expression and ChIP-on-chip data.
Gilad Lerman, Joseph McQuown, Alexandre Blais, Brian D. Dynlacht, Guangliang Chen and Bud Mishra. (2006).
Bioinformatics, 23: 314-320. Abstract
ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene.
Zoulika Kherrouche, Alexandre Blais, Elisabeth Ferreira, Yvan De Launoit and Didier Monté.(2006).
Biochemical Journal, 396: 547–556. Abstract
Constructing transcriptional regulatory networks.
Alexandre Blais and Brian D. Dynlacht. (2005).
Genes and Development, 19(13): 1499-1511. Abstract
Devising transcriptional regulatory networks operating during the cell cycle and differentiation using ChIP-on-chip.
Alexandre Blais and Brian D. Dynlacht. (2005).
Chromosome Research, 13(3): 275-288. Abstract
An initial blueprint for myogenic differentiation.
Alexandre Blais, M. Tsikitis, D. Acosta-Alvear, R. Sharan, Y Kluger and B.D. Dynlacht. (2005).
Genes and Development 19(5): 553-569. Abstract
A common set of gene regulatory networks links metabolism and growth inhibition.
H. Cam, E. Balciunaite, Alexandre Blais, A. Spektor, R.C. Scarpulla, R.A. young, Y. Kluger and B.D. Dynlacht. (2004).
Molecular Cell 16(3):399-411. Abstract
Hitting their targets: an emerging picture of E2F and cell cycle control.
Alexandre Blais and Brian D. Dynlacht. (2004).
Current Opinions in Genetics and Development 14(5):527-532. Abstract
Overexpression
of a dominant negative type II bone morphogenetic protein receptor
inhibits the growth of human breast cancer cells.
F. Pouliot, Alexandre Blais and C. Labrie. (2003).
Cancer Research 63(2):277-81. Abstract
Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.
Alexandre Blais, D. Monté, F. Pouliot and C. Labrie. (2002).
Journal of Biological Chemistry 277(35):31679-93. Abstract
Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer.
Alexandre Blais, Yvan Labrie, Frédéric Pouliot, Yves Lachance, Claude Labrie. (1998).
Biochemical and Biophysical Research Communication 247(1): 146-53. Abstract